VP, Disease Business Unit General Manager, US

From the posting

Job Description Vertex is seeking a seasoned commercial executive to serve as VP U.S. General Manager (GM), accountable for end-to-end business performance, including results delivery, performance management, budget and strategic priorities for their designated portfolio, in the US. The VP GM will lead a fully integrated U.S. Business Unit, with responsibility for commercial execution through cross-functional alignment to sustain market leadership while preparing for future innovation. Key Duties & Responsibilities Owns full P&L responsibility for the U.S. designated Business Unit, delivering against revenue, profitability, and long-range plan commitments Leads an established commercial organization with opportunities for future builds with direct reports across Sales and Marketing Drives cross-functional leadership and decision-making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy Ensures continued excellence in launch execution for future indication expansions, and lifecycle management Develops and maintains a high-performing leadership bench with strong succession planning Serves as enterprise steward of Vertex’s designated therapeutic area franchise in the U.S., balancing near-term performance with long-term sustainability Leads the organization throug…

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